In recent year due to advances in combinational chemistry and newer screening technique the large numbers of new drug candidates are synthesized fastly. Although the rate of discovery of newer drug is high, the major trouble in drug development technique is the poor solubility and bioavailability of drug molecule which gives rise to undesirable effect on dissolution rate and ultimately on absorption. A great deal of effort has been taken to resolve this problem. Among that the solid dispersion technique is one of the noteworthy techniques to improve bioavailability. But in practical point of view one should stumble upon large number of problems (Limitations) during enhancement of bioavailability and dissolution rate of poorly soluble drug by using solid dispersion method. The one of the imperative thing is that, these problems can be overcome by using some techniques. In this article we focused on the practical limitation / problems in solid dispersion technique and the methods to overcome them.
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